Beckman Center for Advanced Light-Sheet Microscopy and Data Science
Click here: Full Text of Request for Proposals
Click here: Addendum #1, Nov 18, 2019
Proposals should be centered around core biological problems (addendum: or chemistry/materials science/other areas) and a research program that is enabled by the dynamic, 3D, and long-term imaging capabilities of advanced light-sheet microscopy. Proposals shall include one-page descriptions of up to 3 distinct research project(s) to which the light-sheet capability will be applied that will represent significant advances within this larger research program. Additional consideration will be given to proposals that include other imaging, sensing, or analysis technologies as an integral part of one or more of the proposed research project(s).
Applicants should propose light-sheet microscope modalities that are both necessary and appropriate for their specific proposed research program, including, but not limited to, super-resolution light-sheet, lattice light-sheet, Airy beam light-sheet, single-optic light-sheet, and multi-photon imaging. Proposals for procurement of commercial systems, instrument build or development, and/or significant adaptation or improvement of existing light-sheet microscopy capabilities will be considered. If any instrumentation development work is proposed, then the proposal must also address the engineering approach and plans to complete the technology development, and how these developments will further the specific biological aims. The Foundation recognizes that these development approaches may be higher risk, and so Full Proposals shall also address alternative strategies that will be pursued should one or more aspects of the new technological developments fail to achieve their proposed performance metrics. Applicants shall identify the configuration of microscope or components and detectors that will be purchased in the proposal and justify why that level of capability is necessary and appropriate for the proposed research program. The Foundation also recognizes that there are rapid advancements being made in the field of light-sheet microscopy, and updates to the exact configuration of the proposed microscope modality will be allowed at the Full Proposal stage and will be considered at the award stage. All equipment purchases and installation must be complete within two years of the program awards, currently anticipated in January 2021.
Successful proposals must also include a detailed plan on how data scientists will be incorporated into the research teams to analyze the magnitude of data generated by the microscope systems, and how such analysis will further the specific biological aims. Applicants are encouraged to explore creative solutions to this challenge, including, but not limited to, collaborations with existing resources at the institution(s), collaborations with other academic or research institutions or National Laboratories, hiring of new faculty, and/or project plans with corporate partners. Proposals shall also include plans for how any new analysis techniques, along with representative data sets to demonstrate these techniques, will be shared with the broader research community. All costs for incorporating the data analysis expertise and data storage infrastructure in the proposed program must be included in the budget for the overall program, with institutional commitment to support the proposed plan.
The proposed program team for this effort can include up to 3 co-PIs, with at least one of the co-PIs having demonstrated experience in successfully managing multi-disciplinary teams. The other optional co-PIs should also have significant roles within the program team, for example, in the research, engineering, or data analysis tasks. Inclusion and support of junior faculty and scientists is also a priority for the Arnold and Mabel Beckman Foundation, and successful proposals shall include interdisciplinary teams that include junior faculty and junior scientists, such as staff scientists, postdoctoral fellows, and graduate students, as integral components of the team. A training plan shall also be developed that specifically addresses how junior scientists will benefit from new training opportunities, especially training programs that will extend beyond the individual Institution or consortium.
The Foundation will consider proposals from individual institutions or from consortia of institutions whose combined resources will address the program requirements. For any consortium application, there must be a “Lead Institution”, defined as the institute that will maintain the purchased equipment on their property and will accept the entire grant award on behalf of the consortium.
The Lead Institution submitting the proposal must be a nonprofit US university or research institution.
One co-PI should be identified as the Lead PI for the team to create an account on the submission portal and submit the final Pre-Proposal on behalf of the full team. The submission portal allows for the addition of collaborators to access and upload documents into the account. Instructions are provided in the submission portal.
Questions regarding eligibility can be directed to Anne Hultgren at InstrumentGrants@beckman-foundation.org.